Tackling Stability Challenges in Self-Amplifying mRNA to Strengthen Early-Stage Development & Set the Foundation for Scale
Time: 12:30 pm
day: Conference Day One - Track 1 - AM
Details:
- Investigating degradation pathways specific to long saRNA constructs to inform IVT design, formulation strategies, and handling conditions from day one
- Identifying and mitigating chemical, enzymatic, and mechanical stressors that accelerate saRNA breakdown during production to improve material quality and consistency
- How to embed stability as a core development parameter to generate high-integrity saRNA suitable for downstream formulation and future clinical scale-up
NOVEL MRNA MODALITY
