Eric Yearley
Associate Director - Biologics Nanoparticle Analytical Development CSL
Seminars
Wednesday 24th September 2025
Tackling Stability Challenges in Self-Amplifying mRNA to Strengthen Early-Stage Development & Set the Foundation for Scale
12:00 pm
- Investigating degradation pathways specific to long saRNA constructs to inform IVT design, formulation strategies, and handling conditions from day one
- Identifying and mitigating chemical, enzymatic, and mechanical stressors that accelerate saRNA breakdown during production to improve material quality and consistency
- How to embed stability as a core development parameter to generate high-integrity saRNA suitable for downstream formulation and future clinical scale-up
NOVEL MRNA MODALITY
