Aidan Cola
Principal Associate Scientist, mRNA Process Development Strand Therapeutics
Seminars
Tuesday 29th September 2026
Panel Discussion: Advancing Purification Strategies for Circular & Self-Amplifying RNA to Improve Purity, Boost Yield, & Enable Scalable, Regulatory-Ready Manufacturing
2:30 pm
Key questions include:
- Are current circRNA purification strategies fundamentally overcomplicated – and where can we simplify without compromising quality?
- How do you balance purity, yield, and scalability when designing purification processes for clinical and commercial manufacturing?
- What will define a “fit-for-purpose” purification platform for circRNA as the field moves toward first-in-human and beyond?
Thursday 1st October 2026
Leveraging High-Throughput Automation & Analytical Development to Accelerate Cross-Modality mRNA & circRNA Process Optimization
3:00 pm
- Exploring lessons learned transitioning process development strategies from self-amplifying RNA to circRNA platforms, including upstream IVT optimization,circularization workflows, and downstream purification considerations
- Demonstrating how automated high-throughput experimentation can accelerate reaction chemistry optimization, analytical assay development, and impurity characterization across emerging RNA constructs
- Discussing approaches to building adaptable, cross-functional manufacturing and analytical frameworks capable of supporting the growing complexity of nextgeneration RNA therapeutics and advanced therapy applications
