Trade-offs between yield and full-length product in RNA manufacturing
Time: 4:30 pm
day: Conference Day One - PM
Details:
- Although an mRNA QC panel has many components, yield and percent full-length product (FLP) cut to the heart of costs and purity.
- The direction of the correlation between yield and FLP can change with study scale (i.e., within vs between constructs, range of tested conditions), but there is strong theoretical and empirical evidence that these two values commonly trade-off against each other.
- Variables to consider when process developing to optimize an mRNA manufacturing process for maximum quantity without compromising quality.
