Leveraging Novel Characterization Techniques to Improve mRNA-LNP Process Consistency & Product Quality
10:10 am - Thursday 1st October 2026
- Utilizing emerging single-particle analysis methods synergistically with ensemble analysis to resolve heterogeneity in mRNA loading of LNPs and mRNA-LNP size
- Strengthening analytical and biophysical characterization to provide feedback into mRNA-LNP manufacturing processes and enable optimization of process conditions that would lead to optimally mRNA -loaded LNPs
- Utilizing a high-resolution characterization-based CMC strategy to develop robust processes and deliver batch-to-batch consistency in mRNA-LNP drug products
- Delivering uniformly loaded mRNA-LNPs with elimination of empty LNPs and, thereby, achieving desired potency at lower doses and improved safety profile
