Leveraging Novel Biophysical & Analytical Techniques to Improve mRNALNP Process Consistency & Product Quality
- Utilizing emerging single-particle analysis techniques to complement ensemble analysis and detect heterogeneity in mRNA loading into LNPs, mRNA-LNP size, and cell transfection efficiency
- Improving characterization to feedback into into mRNA-LNP manufacturing processes to optimize process conditions, reduce empty LNP populations and enhance overall product consistency
- Establishing characterization-based improvement of process consistency and product quality to reduce dose requirement and improve safety profile of enhanced mRNALNP potency, to inform more robust, scalable and purification-aware CMC strategies