Leveraging Identity Assays to Enhance Drug Substance Stability to Preserve Integrity & Extend Usability Across Development Stages
Time: 11:00 am
day: Conference Day Two - Track 1 - AM
Details:
- Incorporating computational modelling to predict sequence based degradation and guide rational design of mRNA Drug Substance to prevent late-stage instability
- Modifying mRNA sequence elements, such as UTRs and secondary structures, to improve inherent drug substance stability during storage and handling
- Leveraging identity assays to confirm transcript and mRNA length integrity and detect degradation over time for ensuring consistent DS quality
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