Innovating mRNA Purification: Overcoming Preclinical Bottlenecks to Enable Scalable, Regulatory-Grade Manufacturing
- Lessons learned from developing purification workflows for both mRNA and DNA in the preclinical setting
- Novel purification approaches to minimize dsRNA, protein, and residual impurity burden
- Strategies to improve yield and reproducibility while reducing reliance on high-cost chromatographic steps
- Considerations for bridging preclinical purification methods with scalable, regulatory-compliant processes for late-stage development