Enabling Scalable Circular RNA Manufacturing Through Optimized Purification & Characterization Strategies
1:00 pm - Thursday 1st October 2026
- Overcoming Structural and Purification Bottlenecks: Explores how addressing the structural complexity of circular RNA (circRNA) allows for tunable purification strategies that simultaneously maximize yield, selectively remove small linear impurities, and consistently achieve ∼95% purity at milligram scales and greater for in vivo applications
- Correlating Purity and Sequence with Expression Dynamics: Highlights critical insights into how circRNA expression levels are tied directly to RNA purity, how translation duration is inversely correlated with immunostimulation, and how expression efficiency remains highly construct-specific based on primary sequence elements
- Advancing Analytics for Next-Gen Therapeutics: Demonstrates the application of stateof-the-art analytical approaches to rigorously confirm circularization and structural integrity, ultimately supporting the scalable, robust production of stable, next-generation RNA therapeutics
